Areas of Research
& Special Interests:

Synaptic Communication

Computational Neuroscience

Glial Cell Physiology

Neurocircuitry

Selected Publications

Educational &
Academic Interests:

Teaching

NSC 5201

Journal Club

On-Off Amacrine
Cell Simulations

Recent Graduate Students

Personal Interests

Manuel Esguerra & Robert F. Miller
Intracellular Calcium Waves in Retinal Glial Cells

Time-lapse fluorometric imaging of an intracellular Ca²⁺ wave evoked in an isolated salamander Muller cell by extracellular ATP.

• Upper 3 waveforms are pixel intensities for Fura flouresence indicating Ca²⁺ concentration in 3 regions of the cell
  • Red = distal (far left portion of the imaged cell)
  • Green = soma (central region of imaged cell)
  • Blue = endfoot (upper and rightmost portion of the imaged cell)
  
  
• Cyan trace shows simultaneous whole-cell patch recording of an inward cation current evoked by the ATP application.
  
  
• The 1 micromolar ATP stimulus is denoted by the black bar
  • To view the movie:
    
    • On Macintosh or Windows platforms, you will need to have a Quicktime plugin installed in your web browser.
      If you need the plugin, you can get it here.
    • On the SGI platform you will need the movieplayer plugin
    • We have not determined if the movie is viewable from the Solaris or Linux platforms.